@fluxStyles

17β-HSD

17β-Hydroxysteroid Dehydrogenase

17β-HSD

17β-Hydroxysteroid Dehydrogenase

Interconverts 17-ketosteroids and 17β-hydroxysteroids. Key in testosterone and estradiol synthesis.

Gene Name

HSD17B1-14

Enzyme Class

oxidoreductase

Molecular Weight

35,000 Da

Protein Structure Databases

Function

Catalyzes the final step in testosterone biosynthesis from androstenedione.

Steroidogenic Pathway

Clinical Significance

This enzyme plays a crucial role in steroid hormone biosynthesis. Genetic variations or inhibition can significantly impact hormone levels and related physiological processes.