@fluxStyles

3β-HSD

3β-Hydroxysteroid Dehydrogenase

Compendium
Enzymes
3β-HSD

3β-HSD

3β-Hydroxysteroid Dehydrogenase

Converts Δ5 steroids to Δ4 steroids. Essential for progesterone and androgen synthesis.

Gene Name

HSD3B1/HSD3B2

Enzyme Class

oxidoreductase

Molecular Weight

42,000 Da

Protein Structure Databases

UniProt: P14060

Function

Catalyzes the oxidation and isomerization of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroids.

Clinical Significance

This enzyme plays a crucial role in steroid hormone biosynthesis. Genetic variations or inhibition can significantly impact hormone levels and related physiological processes.