@fluxStyles

CYP11A1

Cytochrome P450 Family 11 Subfamily A Member 1

Compendium
Enzymes
CYP11A1

CYP11A1

Cytochrome P450 Family 11 Subfamily A Member 1

Cholesterol side-chain cleavage enzyme (P450scc). Catalyzes the rate-limiting step in steroid hormone biosynthesis.

Gene Name

CYP11A1

Enzyme Class

oxidoreductase

Molecular Weight

60,000 Da

Protein Structure Databases

UniProt: P05108 PDB: 3N9Y

Function

Converts cholesterol to pregnenolone in mitochondria. This is the first and rate-limiting step of steroidogenesis.

Clinical Significance

This enzyme plays a crucial role in steroid hormone biosynthesis. Genetic variations or inhibition can significantly impact hormone levels and related physiological processes.