@fluxStyles

CYP17A1

Cytochrome P450 Family 17 Subfamily A Member 1

Compendium
Enzymes
CYP17A1

CYP17A1

Cytochrome P450 Family 17 Subfamily A Member 1

17α-hydroxylase and 17,20-lyase enzyme. Critical for androgen and cortisol synthesis.

Gene Name

CYP17A1

Enzyme Class

hydroxylase

Molecular Weight

57,000 Da

Protein Structure Databases

UniProt: P05093 PDB: 3RUK

Function

Has dual function: 17α-hydroxylase activity for cortisol synthesis and 17,20-lyase activity for DHEA production.

Clinical Significance

This enzyme plays a crucial role in steroid hormone biosynthesis. Genetic variations or inhibition can significantly impact hormone levels and related physiological processes.