@fluxStyles

CYP21A2

Cytochrome P450 Family 21 Subfamily A Member 2

Compendium
Enzymes
CYP21A2

CYP21A2

Cytochrome P450 Family 21 Subfamily A Member 2

21-hydroxylase enzyme. Deficiency causes congenital adrenal hyperplasia (CAH).

Gene Name

CYP21A2

Enzyme Class

hydroxylase

Molecular Weight

55,000 Da

Protein Structure Databases

UniProt: P08686

Function

Hydroxylates progesterone and 17α-hydroxyprogesterone at the 21 position for cortisol and aldosterone synthesis.

Clinical Significance

This enzyme plays a crucial role in steroid hormone biosynthesis. Genetic variations or inhibition can significantly impact hormone levels and related physiological processes.